Heikamp et al. showed that NUP98‐r AML cells are Menin‐dependent and disrupting the Menin‐KMT2A interaction with the Menin inhibitor VTP50469 induced anti‐proliferative effects and survival benefits in mouse AML models driven by NUP98::NSD1 and NUP98::KDM5A.136. This evidence concerns the gene NSD1 and acute myeloid leukemia.