Given that both KMT2A and NUP98 fusion oncoproteins induce similar gene signatures in AML and that the KMT2A protein plays a role in recruiting NUP98 fusion proteins to particular gene loci, more investigation is required to determine whether and to what extent the identity of NUP98 fusion protein target genes is defined by the KMT2A protein complex or NUP98 fusions. Here, KMT2A is linked to acute myeloid leukemia.