While the non‐mutated NUP98::HOXA9 fusion protein bound to genes associated with developmental processes and leukemia, inducing HOX genes, PBX3 and MEIS1 in the context of regions decorated with the activating H3K27ac histone mark, this pattern was lost when the NUP98 N‐terminal IDR was mutated. The gene discussed is NUP98; the disease is leukemia.