Heikamp et al. showed that NUP98‐r AML cells are Menin‐dependent and disrupting the Menin‐KMT2A interaction with the Menin inhibitor VTP50469 induced anti‐proliferative effects and survival benefits in mouse AML models driven by NUP98::NSD1 and NUP98::KDM5A.136. Here, MEN1 is linked to acute myeloid leukemia.