L. fermentum CQPC04 inhibited the expression of IL-1, IL-6, IL-12, COX-2, and iNOS in colitis mice at the serum, messenger RNA (mRNA), and protein levels, lowering the inflammation-causing injury of mediators of inflammation and exhibiting a prophylactic impact on the onset of colitis, according to the findings of Zhou et al. (31). The gene discussed is PTGS2; the disease is colitis.