TGFBR2 and Aortic dissection: According to the 2024 EACTS/STS Guidelines for diagnosing and treating acute and chronic syndromes of the aorta organ, in patients with LDS with TGFBR2 mutation, surgery to replace the intact aortic arch, descending aorta, or abdominal aorta at a diameter of >= 4.5 cm may be considered, or at a diameter of >= 4.0 cm in the presence of high-risk features, such as women with TGFBR2, small body size, severe extra aortic features, and family history of aortic dissection.2