Genes involving the extracellular space and plasma membrane regulators were increased in aggressive MSI‐H CRC tumors (Fig. 1C, upper panel), and tumor antigens (MAGEA3, MAGEA6, MAGEA9B, or MAGEC2) involving in the transcriptional and post‐translational regulations were represented in the aggressive MSI‐H signature (Fig. 1C, lower panel). Here, MAGEA3 is linked to colorectal carcinoma.