Genes involving the extracellular space and plasma membrane regulators were increased in aggressive MSI‐H CRC tumors (Fig. 1C, upper panel), and tumor antigens (MAGEA3, MAGEA6, MAGEA9B, or MAGEC2) involving in the transcriptional and post‐translational regulations were represented in the aggressive MSI‐H signature (Fig. 1C, lower panel). Here, MAGEA6 is linked to neoplasm.