The fluorescence intensities of anti‐EPCAM (Fig. 3K, upper) and anti‐EGFR (Fig. 3K, lower) antibodies were lower at the cell contact point in homotypic CIC structures than on the outer cell surface, suggesting that NK cell‐resistant CT45A1‐expressing outer MSI‐H CRC cells may shield inner cancer cells from the recognition of therapeutic antibodies, contributing to spatial therapeutic resistance. This evidence concerns the gene EPCAM and cancer.