Pre-existent characteristics (age, sex, signs and ­symptoms, comorbidities, complications, etc.)[4,19,20], physiological parameters (SpO2, temperature, PR, consciousness disorders, etc.)[10,19], laboratory indicators (CRP, BUN, white blood cell count, lymphocyte count, D-dimer, platelets, etc.)[8,10,19,20], imaging data [21], viral variant and vaccination status [22,23], treatment methods [20,24], and the corresponding clinical models [8–10,19], as well as combinations of the above, are the most frequent predictive factors of mortality in patients with COVID-19. The gene discussed is CRP; the disease is COVID-19.