An analysis of immune cells infiltration in the TME, revealed that compared to tumour-bearing Rig-I+/+ mice, tumour-bearing Rig-I−/− mice exhibited a significantly greater proportion of CD8+ T cells, no significant change in the proportion of CD4+ T cells, a significantly greater CD8+/CD4+ T-cells ratio, and significantly higher IFN-γ levels in CD8+ or CD4+ T cells (Fig. 3F–K). The gene discussed is RIGI; the disease is neoplasm.