When the CARD domain of RIG-I binds to the SH1 domain of Src, the PxxP motif of RIG-I, competes with the PxxP motif of AKT, for binding to the SH3 domain of Src, which prevents Src from activating AKT, thus inhibiting the stemness of leukaemia cells (Li et al, 2014). The gene discussed is RIGI; the disease is leukemia.