GZMB and neoplasm: We transferred Rig-I+/+ and Rig-I−/− CD8+ T cells into an MC38 tumour-bearing immunodeficient mouse model and confirmed that knocking out Rig-I slowed tumour growth, reduced the tumour volume and weight, increased the infiltration of CD8+ T cells, and enhanced the secretion of the anti-tumour cytokine granzyme-B (Fig. 4B–I).