Other notable findings include the association between HSF4 and the occurrence of cataracts as well as between coronary artery disease and HHIPL1. HSF4 has been implicated in cataract formation in specific canine breeds49 and through a targeted sequencing study of isolated autosomal-dominant lamellar cataracts in a five-generation British family50, but not previously from GWAS or RVAT evidence. The gene discussed is HHIPL1; the disease is cataract.