GCK and type 2 diabetes mellitus: For example, in the GCK gene, rare pLoF and deleterious missense variants with a frequency of <0.0001 are strongly associated with type 2 diabetes in WES (odds ratio, 10.0; P < 10−20) and WGS (odds ratio, 10.1; P < 10−22) but not in IMP (all P > 0.01)34–36.