Using colocalization analysis, 10 of the 47 proteins found in the MR analysis to be linked to a CVD showed a high (>80%) posterior probability (PP) for hypothesis H4, indicating strong evidence to support shared causal variants between proteins and CVD outcomes (CELSR2–CHD and CELSR2–HF; FGF5–CHD; TGFB1–CHD; FES–CHD; FURIN–stroke and FURIN–CHD; PECAM1–CHD; PROCR–CHD; APOE-CHD; PGF–CHD; ATP6V1G2–HF), while eight showed a moderate PP (50–80%) suggesting medium evidence to support colocalization (Fig. 3). Here, CELSR2 is linked to hydrops fetalis.