Pathway analysis of genes downregulated by METTL14 knockdown (P < 0.05, FC < −1.5) revealed key networks that are important for β-cell development and function such as “maturity-onset diabetes of the young,” “FOXA2 and FOXA3 transcription factor networks,” “insulin secretion,” and “type 1 diabetes mellitus” (Fig. 3H,I; Dataset EV5). This evidence concerns the gene INS and type 1 diabetes mellitus.