Further investigation of older mice (2 months of age) showed that depletion of Mettl14, regardless of the timing of Mettl14 depletion during pancreas development, lead to the development of diabetes in Pdx1CreM14KO, Ngn3CreM14KO and Ins1Cre M14KO mice (Fig. 4I). The gene discussed is METTL14; the disease is diabetes mellitus.