PCOLCE and Hepatic fibrosis: Studies in rodents and humans showed that circulating PCPE-1 is positively associated with liver fibrosis (Hassoun et al, 2017; Hassoun et al, 2016) and that systemic depletion of PCPE-1 ameliorates liver fibrosis in a mouse model of MASH (Sansilvestri Morel et al, 2022).