NR1H3 and steatosis: There was a correlation between the pattern of inflammatory infiltrate in our respective models and the pattern of cholesterol crystals, with inflammatory cells noted throughout the liver parenchyma in LXRαW441R/W441R mice, whereas this seemed to be predominantly located in periportal regions in LXRα knockout mice where steatosis was less notable, sparing heavily steatotic pericentral hepatocytes (Fig. 6e–g).