Frequencies of genomic alterations of the main members of the PIK3CA pathway were at large similar among the three cohorts, with the exception of a few genes that were relatively infrequent across study sets and of PIK3CA when the analysis was not restricted to the HR+/HER2- tumours, which is the only subtype represented in the MSK cohort (Table 2). This evidence concerns the gene PIK3CA and neoplasm.