To test if the lack of differences between the triple combination and RMC-4998 with anti-PD-1 was due to the high sensitivity of KPARG12C tumours to RMC-4998 (Fig. 3a), we generated a less responsive cell line, KPAR.M7, derived from an orthotopic lung KPARG12C tumour growing on MRTX849 (see section “Methods”). This evidence concerns the gene PDCD1 and neoplasm.