Moreover, tumour-infiltrating T cells in tumours treated with both RMC-4998 and RMC-4550 showed marked activation, proliferation, and expression of potential anti-tumour cytotoxic molecules, such as TNFα, IFNγ and Granzyme B (Fig. 6d and Supplementary Fig. 6c–e). The gene discussed is IFNG; the disease is neoplasm.