NOS2 and neoplasm: Interestingly, only the combination of RMC-4998 and RMC-4550 induced elevated expression of Nos2, indicating that although either KRASG12C or SHP2 inhibition can drive depletion of immunosuppressive myeloid-driven programmes, only combined inhibition results in the induction of direct anti-tumour myeloid functions (Fig. 5d).