APOB and coronary artery disorder: As shown in Figure 1Panel B and Table 2, across the 10 SNP clusters there appeared to be a positive, graded relationship between genetically predicted %TRL/remnant-C in non-HDL-C and the CHD risk per 10 mg/dL increase in apoB; for SNP cluster 1 the odds ratio was 1.15 [95% CI: 1.11−1.19] while for SNP cluster 10 the odds ratio was substantially and significantly higher at 1.70 [95% CI: 1.52−1.90] (see also Online Table 3 which shows that further MR analyses using methods tolerant of potential SNP pleiotropic effects provide similar results to Table 1) (Central Illustration).