HSF1 and cancer: In addition, tumors are a disease associated with aging, and circulating MOTS‐c levels have been found to decrease with age.[16] Moreover, exogenous MOTS‐c reversed age‐related senescence and prolonged survival time in aged mice, an effect that may be related to the entrance of exogenous MOTS‐c into the nucleus to activate the transcription factor HSF1 and thus heat shock protein expression.[16] Furthermore, an increasing amount of research indicates a notable decrease in MOTS‐c levels in cancer patients.