Furthermore, it's worth mentioning that post‐translational modifications of aminoacyl‐tRNA synthetases may affect their own catalytic activity,[24] thus the regulation of LARS1 by MOTS‐c may not only be limited to ubiquitination, which down‐regulated mTORC1 signaling by affecting the stability of the LARS1 protein, thereby affecting ovarian cancer progression (the non‐classical pathway); but it may also act by affecting the catalytic activity of LARS1 (the classical pathway). Here, MT-RNR1 is linked to ovarian carcinoma.