CD40 and rheumatoid arthritis: scRNA-seq analysis also demonstrated that the double-positive CD206+CD163+ macrophage signature is dominant in the synovium with similar frequencies observed in both healthy and RA synovial tissue (Fig. 6A), while the CD206+CD163+ coexpressing CD40 triple-positive signature and CD40 signaling module is uniquely enriched in RA synovial tissue compared to HC (Fig. 6, B and C), thus confirming our flow cytometric analysis (Fig. 4).