CD4 and systemic lupus erythematosus: Clustering of 55,072 CD4+ T cells from 33 cSLE patients and 11 pediatric healthy donors revealed the full spectrum from naïve to effector/memory CD4 T cell states represented in both SLE patients and in healthy controls (Fig. 6, a and b), including one ISGhi naïve T cell cluster (cluster 6) that was almost exclusively comprised of cells from cSLE patients (Fig. 6 c).