To this end, we hypothesize that the extended period of IFNγ release observed in mice infused with an equivalent dose and surface CAR+ of clone 9 Bz, as compared with clone 9 28z, may indicate that OTOT toxicity was due to extended persistence and proliferation of clone 9 Bz, which may also be visualized by the tumor swelling prior to tumor clearance observed (Fig. 3C). Here, IFNG is linked to neoplasm.