Other histone (e.g. H4K5 and H4K20) and non-histone (VEGFR, human epidermal growth factor receptor 2 (HER2), mitogen-activated protein 3 kinase 2 (MAP3K2), estrogen receptor (ER) and others) substrates of SMYD3 have, however, been discovered since this finding, especially in relation to cancer (Ref. The gene discussed is ESR1; the disease is cancer.