100). Moreover, MYC in macrophages increases the expression of M2-specific genes such as ALOX15, MRC1 and SCARB1. Therefore, MYC can control M2 polarization (Ref. 162). Recent studies have investigated effect of MYC along with TWIST protein. The studies showed that they both work together in order to promote metastasis, recruitment and polarization of macrophages through evoking cytokines release, including CCL2 and IL-13, to facilitate crosstalk between cancer cells and host macrophages that promotes tumour progression (Ref. 101). The gene discussed is CCL2; the disease is neoplasm.