Moreover, it has been documented that PTPN2 single nucleotide polymorphisms (SNPs) are linked to dysfunctional protein products with subsequent increment of proinflammatory cytokines production [14], upregulation of Th2 and Th17, downregulation of TReg, and the development of autoimmunity [15]. This evidence concerns the gene PTPN2 and Autoimmunity.