As most of the autoimmune rheumatic diseases show polygenic inheritance with shared susceptibility loci between different diseases [30, 31] and based on the aforementioned perspectives, this work aimed to study PTPN2 SNPs (rs2542151 T → G and rs7234029 A → G) in Egyptian BD patients trying to find a relation between the two SNPs and disease occurrence, phenotypes and severity. This evidence concerns the gene PTPN2 and Behcet disease.