MUC5AC and gastric cancer: Consistently, RNA-seq transcriptome experiments showed that Ctnnb1Δi.enh;ApcMin/+ CRCs significantly downregulated genes associated with the Wnt signaling pathway, pluripotency of stem cells, and gastric cancer, whereas increased expression of genes related to normal epithelial functions including oxidative phosphorylation, adhesion, protein digestion and absorption, and mucin biosynthesis (Figure 3M–O).