Unlike MCH, orexin positively influences bone formation and is crucial for maintaining bone health.[26] Moreover, a Chinese traditional drug called Zuogui Wan improves trabecular bone microarchitecture in ovariectomy‐induced osteoporosis rats by regulating orexin‐A and orexin receptor.[34] MCH is known to be released from the hypothalamus into the circulation, exerting its effects both centrally and peripherally. This evidence concerns the gene PMCH and osteoporosis.