Univariate logistic regression analysis revealed that age, level of education, hypertension, ASA classification, cerebrovascular accident, TIA, length of preoperative hospital stay, LVEF, eGFR, NT‐proBNP level, duration of surgery and CPB, circulatory arrest, continuous dexmedetomidine infusion, propofol and γ‐aminobutyric acid administration, intraoperative Hb level, RBC transfusion, and infusion of prothrombin complex concentrate and human fibrinogen were potential predictors of POD (p < 0.1; Table 1). The gene discussed is NPPB; the disease is Hypertension.