TLR2 and neoplasm: Although tumor-specific uptake of TLR2L-800 had been previously established for TLR2L-800 in orthotopic human pancreatic xenograft tumors with endogenous expression of TLR2 (26), pharmacokinetics and biodistribution studies herein determined: low uptake of TLR2L-800 in normal pancreas tissue, high uptake of TLR2L-800 in orthotopic human pancreatic xenograft tumors with endogenous expression of TLR2, and clearance of TLR2L-800 via the renal and hepatic pathways.