Retinoblastoma (Rb) is the most common intraocular neoplasm occurring in childrenworldwide, with an estimated incidence of 1 case in 17,000 livebirths(1).It accounts for approximately 3% of all malignant tumors in childhood and is morefrequent in those aged <5 years(2,3).Tumor carcinogenesis is associated with a biallelic mutation of the Rb1 tumorsuppressor gene, which is located on chromosome 13q14.2. This evidence concerns the gene RB1 and retinoblastoma.