Heavy chain sub‐unit of non‐muscle myosin II (NMHCII) protein. Roles in cell‐adhesion, cell divisions, migration and actin cytoskeleton. Myh9 (heavy chain subunit A) and Myh10 expressed at leading edge SBW at E14.5. Model: Knock‐in of motor impaired Myh10 is a dominant‐negative gain‐of‐function interfering with both Myh9 and Myh10 function. PoC spectrum: Exomphalos (100%), ectopia cordis (50%) or split sternum, diaphragmatic hernia and cardiac defects.162, 163Myh10 null mice do not have VBW phenotype.164 See Sections 4.2.5 and 6.1. This evidence concerns the gene MYH9 and diaphragmatic hernia.