ALOX12 and acute kidney injury: For example, myoinositol oxygenase moderates cephaloridine-induced AKI by activating arachidonate 12-lipoxy­genase and the generation of 12-hydroxyeicosatetraenoic acid [66], and Pediococcus acidilactici GKA4 was shown to alleviate cisplatin-induced AKI through the phosphatidylinositol 3-kinase–protein kinase B axis [67].