The hypoxic state of the DLBCL TME plays a fundamental role in immune evasion as hypoxia can induce the expression of immunosuppressive factors, such as VEGF, induce the expression of inhibitory immune checkpoints such as PD‐(L)1, LAG‐3, TIM‐3, CTLA‐4, and CD47121 and modulate pro‐tumorigenic TAMs.122. The gene discussed is CTLA4; the disease is diffuse large B-cell lymphoma.