Table 1 presents the characteristics of individuals grouped by SII quartiles. MetS was diagnosed in 42.48% of the individuals. Individuals were divided into quartiles, distributed as follows: Q1 group, 2 < SII < 321; Q2 group, 321 < SII < 446; Q3 group, 446 < SII < 620 and Q4 group, 620 < SII < 1136. Significant differences were identified among the 4 SII groups regarding age, sex, race, PIR, WC, systolic blood pressure, FPG, TC, TG, HDL-C, Scr, urine albumin to creatinine ratio, glycosylated hemoglobin, SII, education, smoking, alcohol consumption, and hypertension (all P-values < .05). The gene discussed is ALB; the disease is metabolic syndrome.