In addition, in a prospective study enrolled of 232 sepsis patients, the AUC of combination of PaO2/FiO2, RAGE, SP-D, AngII and CXCL16 was 0.881 (95% CI: 0.837−0.925) [47], and in Lorraine's research, AUC of multivariable model (includes SPD, RAGE, IL-8, CC16, IL-6) was 0.750 (95% CI: 0.700−0.840) [28]. The gene discussed is IL6; the disease is Sepsis.