Our results showed that plasma IL-8, RAGE, LIPS, and PaO2/FiO2 of the first day were independent risk factors for onset of ARDS, and model established through the probability value (ln [h (t, X)/h0 (t)] = 0.505×IL-8 + 1.447×RAGE + 0.255×LIPS−0.008×PaO2/FiO2) was obtained and used to predict ARDS in SICU. The gene discussed is CXCL8; the disease is acute respiratory distress syndrome.