TNF and acute lung injury: A previous study suggested that the elevated plasma levels of IL-8 preceded lung injury in transfusion-related acute lung injury (ALI) [18], and it was more closely correlated with ARDS (OR: 3.21,95% CI: 1.41–7.29) than IL-6 (OR: 2.37, 95% CI: 1.32–4.26), IL-10 (OR: 2.22, 95% CI: 1.14−4.34) and TNF-α (OR: 2.45, 95% CI: 1.33−4.51) [19], IL-8 was associated with outcome of ARDS patients [20].