CXCL8 and acute respiratory distress syndrome: In overall enrolled patients, biomarkers in plasma samples of the first day showed that IL-6, IL-8, and AngIIin ARDS patients were higher than those of patients who would not develop ARDS within 7 days after admission to SICU (p  < 0.05), the same was true in patients with extrapulmonary diseases and in moderate, severe ARDS patients.