Additionally, patients suffering from myocardial ischemia and hypoxia-reperfusion display elevated levels of GCN2 and GCN2 expression is elevated in an oxygen-glucose deprivation/reoxygenation (OGD/R) model while its knockdown decreases oxidative stress, inflammation and apoptosis in embryonic rat cardiomyocytes upon OGD/R (Pu et al., 2019; Zhang et al., 2022). The gene discussed is EIF2AK4; the disease is myocardial ischemia.