Using the cis-pQTL instrument definition, an inverse association was found between genetically proxied concentrations of tumor necrosis factor-alfa (TNF-a) and risk of atopic asthma (OR: 0.38, 95%CI: 0.26 to 0.54, p = 9.78 × 10−8) (FDR<5%). The gene discussed is TNF; the disease is atopic asthma.