Using the cis-pQTL definition, the risk of COPD was higher with increased genetically proxied concentrations of interleukin-18 (IL-18) (OR: 1.13, 95%CI: 1.06 to 1.20, p = 1.0 × 10−4) (FDR<5%). This evidence concerns the gene IL18 and chronic obstructive pulmonary disease.