Analysis of GO terms showed that IrDEGs were mainly enriched in processes linked to humoral immune response, immune response activation, leukocyte-mediated immunity, and complement activation through the classical pathway, potentially impacting the advancement of DN via interactions in the Cytokine-cytokine receptor pathway, IL-17 signaling pathway, Chemokine signaling pathway, AGE-RAGE signaling pathway in diabetic complications, MAPK signaling pathway, and TNF signaling pathway. Here, RENBP is linked to liver dysplastic nodule.