The human leucine-rich repeat immunoglobulin-like domain (LRIG) gene family includes: LRIG1, LRIG2, and LRIG3. LRIG1 functions as a tumor suppressor and has demonstrated prognostic value in several human cancers, while less is known about the functions of LRIG2 and LRIG3. High LRIG1 staining intensity and high fraction of LRIG3-positive cells were significantly associated with cervical adenocarcinoma patient survival, and positive correlations were found between LRIG1 and LRIG3 staining intensity and HPV status (50). This evidence concerns the gene LRIG2 and neoplasm.