Logistic regression analysis adjusted for age, sex, hypertension, and CAD showed that patients who have GA genotypes of ACE2 rs2285666 were unlikely to develop fatigue (AOR=0.405 (95% CI: 0.168-0.973); P=0.043), headache (AOR=0.277 (95% CI: 0.110-0.699); P=0.007), loss of smell (AOR=0.373 (95% CI: 0.155-0.901); P=0.028), and dyspnea (AOR=0.197 (95% CI: 0.063-0.613); P=0.005). In addition, patients who have AA genotypes of ACE2 rs2285666 were unlikely to develop dyspnea (AOR=0.843 (95% CI: 0.183-0.040); P=.029). Here, ACE2 is linked to hypertensive disorder.