Logistic regression analysis adjusted for age, gender, hypertension, and CAD was used to investigate the effect of ACE1 rs4343, rs4342, and rs4341 and ACE2 rs2285666 polymorphisms in the susceptibility of COVID-19 infection, the positive case group was compared to the control group, and the ICU group was compared to the control group. The gene discussed is ACE; the disease is Hypertension.