Through intersecting the targets of Sappan lignum with 821 DEGs obtained from the public clinical datasets of PCa, eight core targets of Sappan lignum against PCa were retrieved, containing BCL-2, PTGS2, CCNB1, PGR, AURKA, MET, NR3C1, and ABCG2. This evidence concerns the gene NR3C1 and posterior cortical atrophy.