Several publications, including a large study by MD Anderson Cancer Center, reported significant weight gain in 33.7% of breast cancer survivors with hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative tumors (Gadea et al., 2012; Camoriano et al., 1990; Nichols et al., 2009; Raghavendra et al., 2018). The gene discussed is NR4A1; the disease is breast cancer.