OPRM1 and Timothy syndrome: Figure 3B displayed the profiles of LASSO coefficients for genes that initially fulfilled the prognostic criteria. Number of features versus 5 × CV accuracy plot was shown in Figure 3C. As a result, from the all of 96 intersecting genes obtained in the previous step, the LASSO regression screened out 5 characteristic genes in TS. Besides, the results of SVM algorithm help identified 4 characteristic genes in TS. The intersection of the two parts of genes from two methods resulted in 2 core genes, namely, OPRM1 and VIM, which were further study in our subsequent study (Figure 3).