Immune simulators related to OPRM1 include TNFRSF13B, while immune inhibitors include KIR2DL3 and KIR2DL1. Immune simulators related to VIM include CXCR4 and CD48, while immune inhibitors include TNFSF9 and CD276. The specific roles of these immune-related genes in TS warrant further exploration. Here, CD48 is linked to Timothy syndrome.