Cheng et al. (2023) also found that direct bilirubin, albumin, and estimated glomerular filtration rate (eGFR) were significant factors influencing voriconazole trough concentrations and suggested that eGFR and platelet count should also be considered when administering voriconazole. Besides, Jahan et al. (2015) explored the clinical efficacy and pharmacokinetics of tacrolimus in children with steroid-resistant nephrotic syndrome and found that patients with elevated CREA may have lower trough concentration and AUC0–12 h. The gene discussed is ALB; the disease is nephrotic syndrome.