The patient's clinical manifestations, including malar rash, discoid lupus, and vasculitis rash, along with laboratory findings showing anemia and leukopenia, as well as immunological profile positive for ANA, anti-dsDNA, and anti-Smith antibodies, both highly specific for SLE, support the diagnosis of systemic lupus erythematosus, therefore fulfilling the 2019 EULAR/ACR classification criteria for SLE [1]. The gene discussed is BTG3; the disease is Decreased total leukocyte count.