Serum HE4 levels were higher in pSLE patients with LN (LN+, n = 85; HE4, 57.1 pmol/L; IQR 35.25–137.4) than those without LN (LN−, n = 22; HE4, 40.2 pmol/L; IQR, 30.8–52.48) (P = 0.0086) (Table 2). This evidence concerns the gene WFDC2 and lobular neoplasia.