TP53 and cancer: MYC, TP53, SRF, FOS, NR3C1 showed the highest expression levels, and responded to coculture with prostate epithelial cells by the different ways – normal PNT cells significantly upregulated TP53 and MYC (+3-7-fold, p<0.05) and downregulated NR3C1 (-4-5-fold, p<0.05), whereas cancer cells induced heterogeneous changes in TP53, MYC, FOS, SRF, NR3C1 expression (Figure 3A).