ENPP1 inhibitor, ZXP-8202 with EC50 value of 20 nM in cell based-assay and ZX-8177 with IC50 of 9.5 nM are reported with 37-60% tumor growth inhibition (TGI) for ZX-8177 in CT26 syngeneic mouse model. The gene discussed is ENPP1; the disease is neoplasm.