Meanwhile, we utilized the existing SNP-array intensity data in our previous study (17) and the general population within the DGV database as the reference and found that the frequency of KCTD13 CNV deletion in our cohort was also significantly higher than that in the general population (DGV: 0.05%), indicating its importance as a genetic marker for hypospadias susceptibility. This evidence concerns the gene KCTD13 and hypospadias.