PFKFB3-mediated glycolysis in endothelial cells is critical in angiogenesis and the development of inflammatory diseases, such as retinopathy (Min et al., 2021), pulmonary hypertension (Cao et al., 2019), and metastatic cancers (Yang et al., 2018). Here, PFKFB3 is linked to pulmonary arterial hypertension.