Studies have found that the expression of glycolytic regulatory factor PFKFB3 is significantly upregulated in sepsis lung, especially in lung endothelial cells (Wang et al., 2019), and experimental data show that endothelium-specific PFKFB3-mediated endothelial inflammation, including leukocyte infiltration mediated by increased expression of adhesion molecules, leads to the development of acute lung injury. The gene discussed is PFKFB3; the disease is Sepsis.