In addition, Zinc fingers and homeoboxes 2 (Zhx2) increases glycolytic metabolism in macrophages in a PFKFB3-dependent manner, resulting in enhanced inflammation during sepsis, whereas bone marrow-specific Zhx2 null mice are more resistant to sepsis induced by either LPS or cecal ligation and puncture (Wang et al., 2020). This evidence concerns the gene PFKFB3 and Sepsis.