Therefore, in a mouse model of LPS-induced sepsis, endothelium-specific PFKFB3 deficiency or 3-(3-pyridyl)-1-(4-pyridyl) -2-propenyl-1-one (3PO) inhibition of PFKFB3 significantly reduced pulmonary edema and improved survival. Here, PFKFB3 is linked to Sepsis.