Pneumoconiosis: We identified an indirect effect of SGLT2 inhibition on pneumoconiosis through the family Alcaligenaceae id.2875 (OR: 0.401, 95% CI: 0.249–0.646, P = 1.71×10-4) and X-12719 (OR: 0.701, 95% CI: 0.503–0.975, P =0.035). Here, SLC5A2 is linked to pneumoconiosis.