GPT and obesity due to melanocortin 4 receptor deficiency: The obesity group showed significantly higher BMI standard deviation score (BMI-SDS), fasting glucose, homeostatic model assessment of insulin resistance (HOMA-IR), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), and low-density lipoprotein (LDL) levels than did the control group, whereas high-density lipoprotein (HDL) and triglyceride (TG) levels were similar in the two groups (t-test, Figure 1B).