Similarly, RNA‐seq analysis following microglial specific deletion of Ager, the gene which encodes for RAGE, which has been shown to be upregulated from spatial transcriptomics of mutant SOD1 mice and ALS patient spinal cords (Maniatis et al., 2019), led to broadly restorative homeostatic transcriptome changes (MacLean et al., 2021). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.