The purpose of this work was to systematically explain a novel network for the involvement of [lncRNA (MIAT and PVT1)-miRNA (miR-93-5p and miR-124-3p)-mRNA (SOD-2 and MICA)] and their connections to the downstream cytokine TNF-α in BD development in Egyptian patients. The gene discussed is MICA; the disease is Behcet disease.